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Last updated : May 9, 2019
Methoxetamine (MXE) is a dissociative drug, which means it causes people to feel separated or detached from their body or physical environment. Dissociatives are a type of hallucinogen, which means that they can cause hallucinations and other changes in thoughts, emotions and consciousness.
MXE may also be known as M-ket, Kmax and Mexxy.4
MXE is also a New Psychoactive Substance (NPS). NPSs are a range of drugs that have been designed to mimic existing illicit drugs. In the case of MXE, it attempts to recreate the effects of ketamine and has been marketed and sold online as a legal alternative.1,5,6 However, in some states and territories, NPSs are illegal.
MXE is mostly sold as a white, off-white, beige or yellow powder but can also be found in capsule or liquid form. It is often labelled as “Not for Human Consumption” to avoid legal restrictions regarding the importation and sale of illicit drugs and NPSs. All drugs sold in powder form may be sold cut (mixed) with other substances, which can reduce the purity of the dose and have unintended effects. This means that the effects can be unpredictable.
How is it used?
MXE is usually snorted, swallowed or injected.7
One of the most significant differences between ketamine and MXE is the length of time before its effects are felt. MXE is said to be slower-acting, but more potent and long-lasting.4,5,7 It can take anywhere from 5- 90 minutes to feel the effects. This has led to people overdosing, as they have taken additional doses while waiting for the effect to be felt.1-4 When taken orally, the effects are usually felt within 15–45 minutes. After snorting, the effects are reported to occur within a few minutes.1
There is no safe level of drug use.
Use of any drug always carries some risk. It’s important to be careful when taking any type of drug.
MXE can affect everyone differently, based on:
In small doses the following effects may occur and may last for up to 7 hours: 1,7
Some adverse effects include: 1,4,7
Higher doses or long-term use of MXE can lead to: 1,7,8,9
As with ketamine, long term use of MXE is also associated with kidney damage and cystitis.12
The effects of combining drugs – including over-the-counter or prescribed medications – can be unpredictable and dangerous. There is little evidence available on the effects of MXE when combined with other drugs.10 Anecdotal reports suggest that mixing MXE with alcohol, cannabis and antidepressants should be avoided.1
Use of MXE is likely to be more dangerous when:
Injecting drugs, including MXE, can cause damage to veins and other tissues.
Sharing needles may also transmit:
There is limited evidence regarding MXE and dependence, however, experts believe that the similarity to ketamine means that it carries a comparable risk of dependency.7,10,11 While the Independent Scientific Committee on Drugs (UK) ranks ketamine as less harmful than other illicit drugs such as methamphetamine, heroin, cocaine or GHB13, some studies have indicated a high risk for tolerance and dependency.14
In the days after MXE use, the following may be experienced: