Last published: January 10, 2023
What is amyl nitrite?
Amyl nitrite is a depressant which means it slows down the messages travelling between the brain and body. Classified as an inhalant, it belongs to a class of drugs known as alkyl nitrites, which also includes butyl nitrite, isobutyl nitrite and isopropyl nitrite.1
Amyl nitrite is a vasodilator. Vasodilators are medicines that cause the blood vessels in the body to dilate and the involuntary smooth muscles to relax, lowering blood pressure.2, 3
What does it look like?
Amyl nitrite is an extremely flammable and highly volatile oil that is clear or yellowish in colour and comes in a small glass bottle.2, 4 It typically has a distinct smell similar to dirty socks.4
Poppers, Jungle Juice, liquid gold, rush, purple haze and buzz.
How is it used?
Amyl nitrite has been used medically in the past for the treatment of angina (chest pain), and has been used for the treatment of cyanide poisoning.3, 4
Recreationally, it’s inhaled directly from the bottle and used to enhance sexual experiences or to experience a general sense of pleasure.
Historically, amyl nitrite has been used more by men who have sex with men.5 This is still common; however, it has also become a common ‘party drug’ that is used more widely.6
Effects of amyl nitrite
There is no safe level of drug use. Use of any drug always carries some risk. It’s important to be careful when taking any type of drug.
Amyl nitrite will affect everyone differently, based on:
- size, weight and health
- whether the person is used to taking it
- whether other drugs are taken around the same time
- the amount taken
- the strength of the drug
- environment (where the drug is taken)
- amount of fresh air breathed while inhaling
- amount of physical activity before and after inhaling.
The effects of amyl nitrate are usually felt straight away, and last for around two to five minutes.3 They include:
- initial ‘rush’ of euphoria
- flushing of the face
- increased heart rate
- warming sensations
- feelings of excitement
- involuntary muscle relaxation, especially the anal and vaginal sphincter
- low blood pressure
- slowed breathing
- skin irritation
- blurred vision
- nose bleeds
- psychological effects can include increased sensual awareness, visual distortions, lowered inhibitions and impaired judgement.2, 3, 7, 8
Headaches are common once the ‘high’ passes.3
Set and Setting
Drugs that affect a person’s mental state (psychoactive drugs) can also have varied effects depending on a person’s mood or the environment they are in. This is often called ‘set’ and ‘setting’:
- Set: a person’s state of mind, previous encounters with psychoactive drugs, and expectations of what’s going to happen. For example, feelings of joy, sadness or anger can be magnified when a person drinks alcohol, or feelings of anxiety may be increased when using cannabis.9
- Setting: the environment in which someone consumes a psychoactive drug – whether it’s known and familiar, who they’re with, if they’re indoors or outdoors, the type of music and light. For example, using psychoactive drugs in a calm, quiet and relaxed environment can lead to a different experience than in a noisy, crowded place.9
The level of harm from the long-term use of amyl nitrite is generally low. However, long term effects can range from mild allergic reactions to potentially life threatening methaemoglobinaemia – a blood disorder that causes inadequate oxygen supply to body tissue.10
Frequent use can also cause a rash around the mouth, nose and eyes, or any skin that is in regular contact with the vapour.11 This can look like a skin irritation. Direct fluid contact with skin can cause burns and should be avoided.8
People who are anaemic, pregnant, have a heart condition, have high blood pressure, or have increased pressure within the skull (head injury or brain haemorrhage) should avoid using amyl nitrite as this can increase the risk of harmful effects.3, 12
There’s also a rare risk of maculopathy (loss of vision) most commonly associated with isopropyl nitrite. For people who have underlying glaucoma there’s a risk of fluid pressure build-up within the eye.3, 8, 13
Using amyl nitrite with other drugs
The effects of using amyl nitrite with other drugs – including over-the-counter or prescribed medications – can be unpredictable and dangerous.
- Amyl nitrite + Viagra or other erectile dysfunction medications: a high risk that the person will lose consciousness due to a sudden and extreme drop in blood pressure.12 This may require immediate medical attention – call 000 in case of an emergency.
- Amyl nitrite + amphetamines: increased strain on the heart, placing whole body under extra stress.12
More on Polydrug use
‘Polydrug use’ is a term for the use of more than one drug or type of drug at the same time or one after another.1 Polydrug use can involve both illicit drugs and legal substances, such as alcohol and medications.
Regular use of amyl nitrite use does not result in dependence. People who use it regularly shouldn’t experience withdrawal symptoms, however it may take a few days for their body to get used to not having the drug in their system.3
Health and safety
Some people might be unaware of how amyl nitrite should be used and incorrect use can be fatal.8
Amyl nitrite liquid should not be ingested i.e. do not swallow, as it is a highly poisonous substance that can lead to blindness, brain damage, organ failure and death.3 It’s also a powerful irritant that can lead to burns to the face, skin and eyes.8
If your use of amyl nitrite is affecting your health, family, relationships, work, school, financial or other life situations, or you’re concerned about a loved one, you can find help and support.
Call our DrugInfo line on 1300 85 85 84 for confidential and non-judgmental information and advice.
You can also search our list of Support Services for services in your local area:
Not sure what you are looking for? Try our intuitive Path2Help tool and be matched with support information and services tailored to you.Find out more
Inhalant use is not a criminal offence in any Australian state or territory.15
In recent years, some Australian states and territories have revised police powers to intervene in inhalant use in two main ways. Police are authorised to:
- take away inhalants and related equipment
- pick up young people who are using inhalants, and release them into the care of a responsible person, or a place of safety.15
It’s also illegal in some states and territories to sell or supply products to someone if they believe they are to be used for inhaling.16
As of February 2020, the Therapeutic Goods Administration (TGA) have chosen to down-schedule Amyl Nitrite to a Schedule 3 medicine so that people will be able to purchase it from a pharmacist without needing a prescription.13
State/territory legislation on inhalant sales
It is an offence in Queensland, Western Australia, Victoria, South Australia, and the Northern Territory to knowingly supply an inhalant to a person for the purpose of intentional inhalation.16
- In 2019, 4.8% of Australians aged 14 years or older had used inhalants in their lifetime.17, 18
- Between 2001 and 2019, general inhalant use among Australians aged 14 years or older has increased from 0.4% to 1.4%.17, 18
- In 2009, the prevalence of amyl nitrite use among gay and homosexually active men was at 32%.19
- Therapeutic Goods Administration. Testing of Alkyl Nitrite 'Poppers': Australian Government; 2019
- PubChem.Amyl nitrite: U.S National Library of Medicine; 2019
- Drug Science. Alkyl Nitrites (poppers): Drug Science; 2019
- Upfal J. Australian drug guide : the plain language guide to drugs and medicines of all kinds. Melbourne, Vic.: Black Inc.; 2016.
- Mullens AB, Young RM, Dunne MP, Norton G. The Amyl Nitrite Expectancy Questionnaire for Men who have Sex with Men (AEQ-MSM): A Measure of Substance-Related Beliefs. Substance Use & Misuse. 2011;46(13):1642-50.
- Peacock A, Karlsson, A, Uporova, J, Gibbs, D, Swanton, R, Kelly, G, Price,, O B, R, Dietze, P, Lenton, S, Salom, C, Degenhardt, L, & Farrell, M. Australian Drug Trends 2019: Key Findings from the National Ecstasy and Related Drugs Reporting System (EDRS) Interviews. Sydney: National Drug and Alcohol Research Centre, UNSW Sydney.; 2019.
- Krilis M, Thompson J, Atik A, Lusthaus J, Jankelowitz S. 'Popper'-induced vision loss. Drug And Alcohol Review. 2013;32(3):333-4.
- Therapeutic Goods Administration. Publication of interim decisions proposing to amend, or not amend, the current Poisons Standard, September 2018: 1.3 Alkyl nitrites: Australian Government; 2018
- Nutt DJ. Drugs without the hot air : making sense of legal and illegal drugs. Cambridge: UIT Cambridge Ltd.; 2020 [cited 2021 August].
- Modarai B, Kapadia YK, Kerins M, Terris J. Methylene blue: a treatment for severe methaemoglobinaemia secondary to misuse of amyl nitrite. Emergency Medicine Journal. 2002;19(3):270.
- Schauber J, Herzinger T. 'Poppers' dermatitis. Clinical And Experimental Dermatology. 2012;37(5):587-8. 12. TouchBase. Amyl: Thorne Harbour Health; 2019
- Therapeutic Goods Administration.Final decision(s) for matter(s) referred to the March 2019 Joint ACMS-ACCS meeting: Australian Government; 2019
- World Health Organisation. Lexicon of Alcohol and Drug Terms. World Health Organisation; 1994.
- Department of Health. 10.1 Legislation governing police powers to intervene in VSM: Australian Government; 2019
- Parliament of Australia. Appendix 3 - Legislation relating to inhalant abuse: Parliament of Australia; 2019
- Australian Institute of Health Welfare. National Drug Strategy Household Survey 2019. Canberra: AIHW; 2020.
- Australian Institute of Health and Welfare. National Drug Strategy Household Survey 2016: detailed findings. Canberra: AIHW; 2017.
- Holt M, Mao, L, Prestage, G, Zablotska, I & de Wit, J. Gay Community Periodic Surveys: National Report 2010. Sydney: National Centre in HIV Social Research, The Univeristy of New South Wales; 2011.