Prescription drugs pain killers

Last published: October 07, 2020

What is oxycodone?

Oxycodone hydrochloride is part of a group of drugs known as opioids. Opioids interact with opioid receptors in the brain and elicit a range of responses within the body, from feelings of pain relief, to relaxation, pleasure and contentment.

Oxycodone is most commonly prescribed by doctors to relieve moderate to severe pain. However, there is increasing concern among medical professionals about the risks of using these drugs, particularly when they are used for a long time.

Under the Pharmaceutical Benefits Scheme (PBS), oxycodone is a Schedule 8 drug. Doctors must follow state and territory laws when prescribing oxycodone and must notify, or receive approval from, the appropriate health authority.

Some people use oxycodone to become intoxicated, which can result in serious side effects.

Types of oxycodone

Oxycodone comes in a number of forms including capsules, tablets, liquid and suppositories. It also comes in a variety of strengths.

Common oxycodone brand names

Oxynorm®, OxyContin®, Endone®, Proladone®, Targin®.

Slang names

Hillbilly heroin, oxy, OC and O.

How are they used?

Oxycodone is usually swallowed but is sometimes injected or used as a suppository.

To prevent OxyContin® tablets being injected, they were reformulated in 2014. The tablets are now resistant to crushing and become a thick gel when added to water. They also have controlled release properties, even as a gel. Read more about this change on the ReGen website.

Effects of oxycodone

Use of any drug always carries some risk. It’s important to be careful when taking any type of drug and follow your doctor’s prescription. Contact your doctor if you are concerned about the side effects of oxycodone.

Oxycodone affects everyone differently, but the effects may include:

  • pain relief
  • dizziness or faintness
  • tiredness
  • confusion and difficulty concentrating
  • euphoria or negative mood
  • restlessness
  • stiff muscles
  • constipation
  • dry mouth
  • stomach ache and nausea
  • difficulty urinating
  • slow pulse
  • excess sweating, flushing and itching
  • mild allergic rash or hives (see your doctor promptly).1

If injecting drugs there is an increased risk of:

  • tetanus
  • infection
  • vein damage.

If sharing needles there is an increased risk of:

  • Hepatitis B
  • Hepatitis C
  • HIV and AIDS.

Injecting drugs repeatedly and sharing injecting equipment with other people increases the risk of experiencing these effects.


If you take a large amount of oxycodone, you could overdose. Call an ambulance straight away by dialling triple zero (000) if you have any of these symptoms (ambulance officers don’t need to involve the police):

  • chest pain or discomfort
  • small pupils
  • decreased awareness or responsiveness
  • extreme drowsiness and loss of consciousness
  • no muscle tone or movement
  • slow or irregular heartbeat.1

Note: If possible, have the medicine with you so the ambulance officers know what has been taken.

Long-term effects

Regular use of oxycodone may cause:

  • dental problems2
  • mood swings
  • reduced sex drive and decreased level of testosterone (males) and menstrual problems (females)
  • needing to use more to get the same effect
  • financial, work or social problems.3

Using oxycodone with other drugs

The effects of taking oxycodone with other drugs can be unpredictable and dangerous, and could cause:

  • Oxycodone + alcohol: increased confusion and clumsiness, and breathing difficulties.
  • Oxycodone + some antidepressants (monoamine oxidase inhibitors – MAOIs): delirium, convulsions, respiratory failure, coma and death.4


Giving up oxycodone after using it for a long time is challenging because the body has to get used to functioning without it. This is why it’s important to seek advice from a health professional when planning to stop taking oxycodone, whether you have been taking it with a prescription or not.

Withdrawal symptoms vary from person to person and are different depending on the type of oxycodone taken. Symptoms usually last for approximately one week and can include:

  • watering eyes
  • runny nose
  • uncontrollable yawning
  • difficulty sleeping and severe restlessness
  • hot and cold flushes
  • pains in muscles and joints
  • muscle spasms and tremors
  • loss of appetite, nausea and vomiting
  • increased heart rate and blood pressure
  • uncontrolled kicking movements.3

Getting help

If your use of oxycodone is affecting your health, family, relationships, work, school, financial or other life situations, you can find help and support.

Call 1300 85 85 84 to speak to a real person and get answers to your questions as well as advice on practical ‘next steps’.

You can also search our list of Support Services for services in your local area:

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The amount of oxycodone being prescribed by doctors increased from 97kg in 1997 to 1295kg in 2008.5

Under the Pharmaceutical Benefits Scheme (PBS), oxycodone is a Schedule 8 drug. Doctors must follow state and territory laws when prescribing oxycodone and must notify, or receive approval from, the appropriate health authority.

Using oxycodone without a prescription from a doctor, or selling or giving them to someone else, is illegal. There are also laws against forging or altering a prescription or making false representation to obtain oxycodone or a prescription for them from a health professional.

See also, drugs and the law.

  1. Mayo Clinic. (2014) Oxycodone (oral route).
  2. Migraine Awareness Group. (n.d.) Treatment & Management Drug Profiles: oxycodone HCI, controlled-release OxyContin.
  3. Brands, B. Sproule, B. & Marshman, J. (Eds.). (1998). Drugs & drug abuse (3rd ed.). Ontario: Addiction Research Foundation.
  4. Upfal J. (2006). The Australian drug guide (7th ed.). Melbourne: Black Inc.
  5. Rintoul, A.C., Dobbin, M., Drummer, O.H., & Ozanne-Smith, J. (2011). Increasing deaths involving oxycodone, Victoria, Australia, 2000-09. Injury Prevention, 17(4), 254–259.

Explore opioids on the Drug Wheel

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blurred vision, confusion, constipation, difficulty concentrating, difficulty urinating, dizziness, dry mouth, euphoria, excessive sweating, faintness, flushing and itching, hives, nausea, negative mood, pain relief, restlessness, stiff muscles, stomach pains, tiredness


O, OC, hillbilly heroin, oxy