Last updated : October 3, 2018

What is buprenorphine?

Buprenorphine (pronounced bew-pre-nor-feen) is a prescription drug.

It is taken as a replacement in the treatment of heroin and methadone dependence. Replacing a prescribed drug to treat a drug of dependence in this way is known as pharmacotherapy.  As well as improving wellbeing by preventing physical withdrawal, pharmacotherapy helps to stabilise the lives of people who are dependent on heroin and other opioids, and to reduce the harms related to drug use.

Buprenorphine pharmacotherapy can be used to:

  • Help people to withdraw from heroin and methadone
  • Reduce the need to use heroin – this is known as buprenorphine maintenance
  • Treat severe pain1

Other names

Pharmaceutical name

There are two formulations of buprenorphine available for people on pharmacotherapy treatment in Victoria:

  • Suboxone Sublingual Film® – A combination of buprenorphine and naloxone (also known as Narcan®). This is the most widely used form
  • Subutex Sublingual Tablets® – Contains only buprenorphine2

Slang names

Bup, B

How is it used?

Suboxone Sublingual Film® is a lime-flavoured, rectangular, orange film, which is placed under the tongue to dissolve. The film will not work properly if it is chewed or swallowed.3

Subutex Sublingual Tablets® are also placed under the tongue to dissolve and will not work properly if chewed or swallowed.4

How effective is it?

Buprenorphine treatment is more likely to be successful if it is part of a comprehensive treatment program, which addresses the body, mind and environment in which heroin has been used.

For example, treatment may include a combination of buprenorphine, counselling, alternative therapies and the development of a positive support network of peers, friends and a support group.1

Buprenorphine maintenance

Buprenorphine maintenance may not work for everyone, so it is important to work with a doctor or drug counsellor to find the best approach.

Advantages of buprenorphine maintenance over heroin use

  • Using buprenorphine on its own is unlikely to result in an overdose
  • Buprenorphine maintenance keeps the person stable while they make positive changes in their lives
  • Health problems are reduced or avoided, especially those related to injecting, such as HIV, hepatitis B and hepatitis C viruses, skin infections and vein problems
  • Doses are required only once a day, sometimes even less often, because buprenorphine’s effects are long lasting
  • Buprenorphine is much cheaper than heroin5

Effects of buprenorphine

There is no safe level of drug use. Use of any drug always carries some risk. Even medications can produce unwanted side effects. It’s important to be careful when taking any type of drug.

Buprenorphine affects everyone differently, based on:

  • Size, weight and health
  • Whether the person is used to taking it
  • Whether other drugs are taken around the same time
  • The amount taken

Side effects

The most common side effects of buprenorphine are:

  • Constipation
  • Headache
  • Increased sweating
  • Tiredness or drowsiness (especially after a dose)
  • Loss of appetite, nausea and vomiting
  • Abdominal pain
  • Skin rashes, itching or hives
  • Tooth decay
  • Changes to periods (menstruation)
  • Lowered sex drive (males and females)
  • Weight gain (particularly for females)1


Withdrawal from long-term use of buprenorphine may produce some symptoms similar to those experienced through heroin withdrawal. However, symptoms tend to be milder than for heroin or other opioids such as methadone withdrawal.1 Withdrawal symptoms vary from person to person, but may include:

  • Cold or flu-like symptoms
  • Headache
  • Sweating
  • Aches and pains
  • Difficulty sleeping
  • Nausea
  • Mood swings
  • Loss of appetite1

These effects usually peak in the first 2 to 5 days. Some mild effects may last a number of weeks.

Buprenorphine statistics

Pharmacotherapy drugs (methadone, buprenorphine and naloxone)

On a snapshot day in June 2016, 48,900 clients were receiving pharmacotherapy treatment in Australia. 60% received methadone, 20.8% received buprenorphine–naloxone and 14.3% received buprenorphine.6

Buprenorphine and the law

Using buprenorphine without a prescription from a doctor, or selling or giving it to someone else, is illegal. There are also laws against forging or altering a prescription or making false representation to obtain buprenorphine or a prescription for it.7

  1. Lintzeris. N, Clark. N, Winstock. A, Dunlop. A, Muhleisen. P, Gowing. L, Ali. R, Ritter. A, Bell. J, Quigley. A, Mattick. RP, Monheit. B., & White. J. (2006). National clinical guidelines and procedures for the use of buprenorphine in the treatment of opioid dependence [PDF:3MB].
  2. Harm Reduction Victoria. (n.d.) Buprenorphine (Subutex).
  3. NPS MedicineWise (n.d.) Suboxone Sublingual Film.
  4. NPS MedicineWise (2018) Subutex Sublingual tablets
  5. Wodak, A., (2001). Drug treatment for opioid dependence.
  6. Australian Institute of Health and Welfare. (2016). Opioid pharmacotherapy clients (NOPSAD 2016)
  7. Drugs, Poisons and Controlled Substances Act 1981 – Sect 36B.


abdominal pain, changes to periods, constipation, drowsiness, headache, hives, increased sweating, loss of appetite, lowered sex drive, nausea, Pharmacotherapy, skin rashes, tiredness, tooth decay, treat severe pain, vomiting, weight gain, withdraw from heroin, withdraw from methadone.


b, bup.