Aspirin

Aspirin-930x940.jpg

Last published: June 20, 2024

What is aspirin?

Aspirin (acetylsalicylic acid) is a pharmaceutical drug used to reduce pain or inflammation.1-3 It is classified as a non-steroidal anti-inflammatory drug (NSAID). It can be used to treat:

  • mild to moderate pain
  • fever
  • swelling 4,5

Some people are prescribed aspirin at low doses over a long time, to help reduce the risk of heart attack and stroke. This is known as ‘aspirin therapy’.6-9 Caution is advised when using aspirin for this, as it can increase the risk of:

  • peptic ulcers (stomach and small intestine)
  • bleeding
  • gastrointestinal bleeding (stomach and small intestine)
  • intracranial bleeding (bleeding within the brain).10-15

What does aspirin look like?

Aspirin comes in different forms including:

  • tablet
  • capsules
  • soluble or chewable
  • suppository
  • liquids.4

Other names

Aspirin may also be known by its brand or trade names. Some common examples include:

Generic name Brand names
Aspirin Aspro Clear®, Disprin®
Aspirin and codeine Aspalgin®, Codral Cold & Flu Original®

How is aspirin used?

Aspirin is usually swallowed. In a healthcare setting, it can be injected or inserted in the rectum.16

Effects of aspirin

Use of any drug can have risks. It’s important to be careful when taking any type of drug.

Aspirin affects everyone differently, based on:

  • size, weight and health
  • whether the person is used to taking it
  • whether other drugs are taken around the same time
  • the amount taken
  • the strength of the drug (varies by brand).

Side effects

The most common side effects of aspirin are:

  • dizziness
  • ringing in the ears
  • blurred vision
  • drowsiness and fatigue
  • thirst and sweating
  • swollen ankles
  • abdominal discomfort or bloating
  • nausea
  • heartburn
  • diarrhoea
  • constipation.4

Overdose

If you take a large amount of aspirin, you could overdose. Overdose symptoms usually occur within 6-12 hours of taking aspirin.17

Asprin can cause death. Call an ambulance straight away by dialling triple zero (000) if you, or someone else, has taken too much aspirin or is experiencing any of the following symptoms:

  • nausea or vomiting
  • trouble breathing (rapid or shallow breath)
  • ringing ears or unable to hear
  • sweating
  • fever
  • confusion
  • seizures
  • coma.4

Long-term effects

Regular use of aspirin may eventually cause:

  • anaemia (low red blood cell count)
  • easy bruising and abnormal bleeding
  • inflamed stomach lining, stomach bleeding, and peptic ulcers
  • vomiting blood that look like coffee grounds
  • bowel motions that look like black tar
  • in some rare cases swelling of the face, lips, tongue or around the eyes
  • reduced kidney and liver function.18

Tolerance and dependence 

Aspirin does not produce tolerance or dependence, though some people may develop a psychological dependence on the drug.19

Mixing aspirin with other drugs

Mixing aspirin with other drugs can have unpredictable effects and increase the risk of harm.

  • Aspirin and alcohol: can increase the risk of stomach irritation and discomfort.
  • Aspirin and warfarin/other blood thinning medicines: may increase the risk of bleeding.
  • Aspirin and Ibuprofen: combining these medications may increase your risk of developing gastrointestinal ulcers and bleeding.4,20

Use of more than one drug or type of drug consumed at the same time is called polydrug use.22

More on Polydrug use

Polydrug use is a term for the use of more than one drug or type of drug at the same time or one after another. Polydrug use can involve both illicit drugs and legal substances, such as alcohol and medications.

READ MORE

Reducing Harm

There are ways you can reduce the risk of harm when taking aspirin:

  • Check with your doctor/pharmacist before taking aspirin, especially if you use other medications or are pregnant/breastfeeding
  • Follow directions on packet and don’t exceed recommended dose within 24-hour period
  • People with haemophilia and other bleeding disorders, liver or kidney damage, or gout should consult with their doctor before using aspirin.
  • Consult your doctor if you have any other underlying health conditions that could interact with aspirin.
  • Avoid long-term use of aspirin where possible.18,20,21

Withdrawal

If the recommended dose is taken , no withdrawal effect should occur.

If you stop taking aspirin suddenly or miss a dose when receiving aspirin therapy, it can increase the risk of cardiovascular events and be dangerous.23

Getting help

If your use of aspirin is affecting your health, family, relationships, work, school, financial or other life situations, or you’re concerned about a loved one, you can find help and support.

Call the National Alcohol and Other Drug Hotline on 1800 250 015 for free and confidential advice, information and counselling about alcohol and other drugs

Help and Support Services search

Find a service in your local area from our list. Simply add your location or postcode and filter by service type to quickly discover help near you.

If you're looking for other information or support options, send us an email at druginfo@adf.org.au

Path2Help

Not sure what you are looking for?
Try our intuitive Path2Help tool and be matched with support information and services tailored to you.

Find out more
Image of a woman walking through a maze

Aspirin is available for general sale to the public (over the counter), and via a prescription.

About 1 in 9 (11.9%) Australians aged 14 and over have used a pharmaceutical for non-medical purposes in their lifetime.24

  1. Sudhakar V, Vinodhini TS, Mohan AM, Srinivasan B, Rajkumar BK. The efficacy of different pre- and post-operative analgesics in the management of pain after orthodontic separator placement: A randomized clinical trial. Journal of Pharmacy & Bioallied Sciences [Internet]. 2014 [14.06.2024]; 6(S1):[S80-S4 pp.].
  2. Voelker M, Schachtel S, Cooper S, Gatoulis S. Efficacy of disintegrating aspirin in two different models for acute mild-to-moderate pain: sore throat pain and dental pain. Inflammopharmacology [Internet]. 2016 [14.06.2024]; 24(1):[43-51 pp.].
  3. Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, et al. Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans. The Journal of Immunology [Internet]. 2009 [14.06.2024]; 183(3):[2089 p.].
  4. Upfal J. Australian drug guide : the plain language guide to drugs and medicines of all kinds. Melbourne, Vic.: Black Inc.; 2016 [05.06.2024].
  5. NPS Medicine Wise. Astrix capsules: Australian Government Department of Health and Aged Care; 2022 [07.05.24].
  6. Henrekens C. Steering Committee of the Physicians Health Study Research Group Final report on the aspirin component of the ongoing Physicians Health Study. N Engl J Med [Internet]. 1989 [14.06.2024]; 321:[129-35 pp.].
  7. Medical Research Council's General Practice Research Framework. Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. The Lancet [Internet]. 1998 [14.06.2024]; 351(9098):[233-41 pp.].
  8. Passarelli MN, Barry EL, Zhang D, Gangar P, Rees JR, Bresalier RS, et al. Aspirin, folic acid and risk of basal cell carcinoma. British Journal of Dermatology [Internet]. 2018 [14.06.2024]; 179(2):[e110-e pp.].
  9. Featherstone C. Aspirin for bowel cancer: an old friend finds a new role. The Lancet [Internet]. 1997 [14.06.2024]; 350(9075):[418 p.].
  10. Bosetti C, Santucci C, Gallus S, Martinetti M, La Vecchia C. Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019. Annals of Oncology [Internet]. 2020 07.05.2024]; 31(5):[558-68 pp.].
  11. Cuzick J, Thorat MA, Bosetti C, Brown PH, Burn J, Cook NR, et al. Estimates of benefits and harms of prophylactic use of aspirin in the general population. Annals of Oncology [Internet]. 2014 [07.05.2024]; 26(1):[47-57 pp.].
  12. Barbarawi M, Kheiri B, Zayed Y, Gakhal I, Al-Abdouh A, Barbarawi O, et al. Aspirin Efficacy in Primary Prevention: A Meta-analysis of Randomized Controlled Trials. High Blood Pressure & Cardiovascular Prevention: The Official Journal Of The Italian Society Of Hypertension [Internet]. 2019 [14.06.2024]; 26(4):[283-91 pp.].
  13. Cook, Lee, Zhang, Moorthy, Buring. Alternate-Day, Low-Dose Aspirin and Cancer Risk: Long-Term Observational Follow-up of a Randomized Trial2013 [14.06.2024]; (2):[77 p.].
  14. Biccler J, Bollaerts K, Vora P, Sole E, Rodriguez LAG, Lanas A, et al. Public health impact of low-dose aspirin on colorectal cancer, cardiovascular disease and safety in the UK – Results from micro-simulation model. IJC Heart & Vasculature [Internet]. 2021 [07.05.2024]; 36.
  15. Huang W-Y, Saver JL, Wu Y-L, Lin C-J, Lee M, Ovbiagele B. Frequency of Intracranial Hemorrhage With Low-Dose Aspirin in Individuals Without Symptomatic Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Neurology [Internet]. 2019 [07.05.2024]; 76(8).
  16. Drugs.com. Aspirin (rectal)2023 [14.06.2024].
  17. Pearlman BL, Gambhir R. Salicylate Intoxication: A Clinical Review. Postgraduate Medicine [Internet]. 2009 [14.05.2024].
  18. National Kidney Foundation. Watch out for your kidneys when you use medicines for pain United States: National Kidney Foundation; 2019 [07.05.2024].
  19. Goldrich D, Sreedhar A, Aziz R, Kaufman KR, Tobia A, Trenton A. Aspirin misuse: a case report. Bjpsych Open [Internet]. 2019 [14.06.2024]; 5(5):[e65-e pp.].
  20. Drugs.com. Aspirin 2024 [14.06.2024].
  21. The Royal Children's Hospital Melbourne. Haemophilia Australia: Haemophilia Foundation Australia; 2018 [14.06.2024].
  22. Darke S, Lappin, J. & Farrell, M. The Clinician's Guide to Illicit Drugs. United Kingdom: Silverback Publishing 2019.
  23. Doutremepuich C, Aguejouf O, Desplat V, Eizayaga FX. Aspirin Discontinuation Syndromes: Clinical Implications of Basic Research Studies. American Journal of Cardiovascular Drugs [Internet]. 2013 [17.05.24].
  24. Australian Institute of Health and Welfare. National Drug Strategy Household Survey 2022–2023 2024 [14.06.2024].

Effects

abdominal pain , anti-inflammatory , blurred vision , confusion , constipation , depression , diarrhoea , dizziness , drowsiness , fatigue , fluid retention , headache , nausea , ringing ears , seizures , tingling in hands and feet , treats arthritis , treats fever , treats inflammation , treats mild pain , treats moderate pain , vomiting

AKA

aspro clear , disprin